Category: Immune System-Brain Connection

The Microbiome and the Basal Ganglia in …The Case of the Leaky Gut?

I recently read an article looking at the effects of bacterial microbiome alterations on particular circuits in the brain (the thalamo-cortico-basal ganglia)  that are associated with compulsive behavior, addiction, altered sensations and motor output.[i]  What struck me is how closely related seemingly unrelated disorders…

Fecal Microbiota Transplant: the Answer for Alzheimer’s Disease?

Ok, yeah…more on fecal microbiota transplants (FMT).  This is my obsession for the week. But after reading my last post…can you blame me?! In that post, in case you missed it, I talked about a new article reviewing the potential of FMT to treat…

Probiotics for Chronic Fatigue and Fibromyalgia? Probably, but the Science Isn’t Yet There

As regular readers know, I’m always on the lookout for “things you can do now.”  I’m especially happy then when actual clinical trials happen as we can get some idea of the effectiveness of treatments.  About 18 months ago, a paper was published reviewing…

Ameliorating the Adverse Effects of Excess Propionic Acid

I am officially declaring this Biome Buzz’ first annual Propionic Acid Week! (Unfortunately, this is not a cause for celebration.) If you remember, propionic acid (PPA) is a short-chain fatty acid produced by gut bacteria.  Ordinarily, PPA , like the other SCFAs, is great…

Is There Any Doubt Left that Propionic Acid is a Cause of Autism? Apparently not

I first started to write about autism and propionic acid (PPA) not long after creating this blog, back in the fall of 2016.  In January 2017, I described to you some of the work of Dr. Derrick MacFabe, which as particularly fascinated me for…

The Two Sides of Bacteroides fragilis

Back in May, 2018, I wrote about Bacteriodes fragilis (B. fragilis), a species of bacteria some strains of which are toxic, some of which are highly beneficial.  The main thrust of that post was about how our immune system, when functioning properly, can recognize…

Neurodegnerative and Neuropsychiatric Disorders: Prime Targets for Helminths

Within just a few weeks of each other, two papers have been published looking at the potential of using helminths to treat neurological conditions.  Not surprisingly, both focus on the powerful anti-inflammatory effect of helminths. (For those of you new to helminths:  these are…

Autism and Clostridia: Mounting Evidence of a Connection

As you know, I’ve been following the research of Dr. Derrick MacFabe for well over a decade now.  I’ve described it before on this blog, several times, including this first post 2 ½ years ago – to which, if you remember, Dr. MacFabe was…

Constipation, Dysbiosis, Autism and a Prebiotic: A New Clinical Trial

The single most common gastrointestinal (GI) complaint I hear as a nutritionist, by a long way, is constipation…and the single best piece of advice I give my clients is “drink more water.”  It never ceases to amaze me how dehydrated most people are.  Invariably,…

Fibromyalgia: Yet Another Biome Related Illness

I’ve written before about recent findings that alterations in the gut bacteria are associated with chronic fatigue syndrome (CFS), which is closely related to fibromyalgia.  For those of you unfamiliar, the symptoms of fibromyalgia include wide spread body pain, fatigue, impaired sleep, potentially cognitive…