My regular readers know that I have been closely following the growing body of research into the effects of glyphosates on human health. There has been huge controversy over this for years now. While humans do not have the shikimate pathway that glyphosate (the active ingredient in the herbicide, Roundup) disrupts, bacteria, fungi and plants do do. There is growing belief in the scientific community that even low exposures to the chemical disrupts the bacterial microbiome, leading to health issues in the host.
For obvious reasons, today’s study was performed on rats, not humans, and was published in a very eminent journal, Scientific Reports.[i] The scientists administered Roundup and pure glyphosate in amounts equivalent to what is considered safe for humans (1.75 mg/kg/day)) to dams and their pups. They then measured urine metabolites. They found that there was a big difference in metabolites between the moms and their babies, and interestingly, between male and female pups.
Some interesting facts from the paper:
The most startling finding was that in the male pups, there was significantly increased the amino acid homocysteine, which is a huge risk factor for cardiovascular disease and which has been also found at elevated levels in autism. Actually, homocysteine level is also considered a marker for longevity and inflammatory status in the body. Further analysis found an inverse correlation between Prevotella and homocysteine: the lower the Prevotella, the higher the homocysteine level…and vice versa.
The authors point out that “…studies found that children with autism spectrum disorder (ASD) lack microbial diversity and have a decreased abundance in probiotics including Prevotella, potentially leading to reduce folate production by microbiota in individuals with ASD. As ASD as well as brain damage, cognitive and memory decline have been linked with higher levels of homocysteine, we hypothesize that induced homocysteine by environmental exposure to GBHs during early life may contribute to the development of ASD or other neurodevelopmental disorders.”
The conclusion: exposure to glyphosate at even currently acceptable levels leads to alterations in the urine metabolome in both rat pups and adults, with male pups being particularly susceptible.
This is really scary stuff.
[i] Hu J, Lesseur C, Miao Y, Manservisi F, Panzacchi S, Mandrioli D, Belpoggi F, Chen J, Petrick L. Low-dose exposure of glyphosate-based herbicides disrupt the urine metabolome and its interaction with gut microbiota. Sci Rep. 2021 Feb 5;11(1):3265. doi: 10.1038/s41598-021-82552-2. PMID: 33547360; PMCID: PMC7864973.
Category: Anxiety and PTSD, autism, Bacterial Microbiome, Cardiovascular Disease, depression, Diabetes, inflammation, Mental Health, Metabolic Syndrome, microbiome, obesity, toxinsTags: anxiety, autism, bacterialmicrobiome, cardiovasculardisease, depression, Diabetes, gutbacteria, health, inflammation, mentalhealth, metabolicsyndrome, microbes, microbiome, obesity, toxins