I found a bunch of new research on helminths and will, over the next month or so, make my way through the papers. I wanted to share first an article just published by researchers in Australia (where some of the best hookworm (Necator americanus) research is currently taking place, describing a new clinical study they will be conducting.[i] I have most of the first page highlighted, to share with, as it describes their justification for the study. It’s incredibly compelling – especially as you know that the obesity epidemic is a topic of particular interest to me. (As I have said a million times before – it’s NOT as simple as “eat less”!)
Here are some of the high points of the “why we need to do this trial.
I warn you: this is truly shocking. Take a deep breathe before reading.
So, why use helminths to try to treat this global disaster?
This study will be conducted on 45 obese, but otherwise healthy men and women, aged 18-50, over 24 months. It will be randomized, double-blind, placebo-controlled so the gold-standard of human clinical trials. The researchers will be measuring body fat composition, inflammatory status, immune response, metabolic status (i.e. insulin sensitivity, etc.), microbiome analysis.
They conclude with 2 sentences I must share:
Well, everyone…you have to admit that I said it first. Ha! (The Biome Buzz is so where it’s at. Just one more example, here, because I’ve earned bragging rights.) :- )
[i] Pierce, D, et. al. Safety and tolerability of experimental hookworm infection in humans with metabolic disease: study protocol for a phase 1b randomized controlled clinical trial. BMS Endocrine Disorders. 2019;19:136. https://doi.org/10.1186/s12902-019-0461-5
Category: allergy, asthma, autism, Autoimmune Disease, Bacterial Microbiome, cancer, Cardiovascular Disease, Crohn's, Crohn's Disease, Diabetes, Helminthic Therapy, Human Biome, inflammation, Inflammatory Bowel Disease, Macrobiome, Metabolic Syndrome, microbiome, obesity, stroke, Ulcerative ColitisTags: asd, asthma, autism, bacterialmicrobiome, cancer, cardiovasculardisease, children, cholesterol, Crohn's, Diabetes, gutbacteria, health, helminthictherapy, ibd, Macrobiome, metabolicsyndrome, microbes, microbiome, obesity, ulcerativecolitis