As I promised last Thursday, I’ll finish talking about the article[i] on aging, the microbiome, and senescence today.
A quick summary of my last post: the evidence currently available points to a depletion of the microbiota as we age (from diet (for example, older people – who may have dental issues – may not eat enough fibrous foods, etc.)), use of antibiotics throughout life, stress associated with aging and so forth: “…these old-age-related clinical issues could clearly contribute to the increased predisposition to various infections and gut-associated diseases by causing alterations in the microbiota of elderly people.” Also, the build-up of senescent cells (especially cells of the immune system) may also result from microbiome depletion, as the gut bacteria are crucial for normal immune functioning. “…however, we still do not have a complete understanding of the mechanisms underlying the aging-mediated changes in the gut microbiome configuration, or whether these microbial changes are the cause of consequence of senescence.”
While we wait (hopefully, not too long) for science to provide us an easy way of “spring cleaning” – lowering our levels of senescent cells (see my last post for more on this) – the article provides us some things we can do now…which, as you know, is my favorite thing to write about.
The article concludes with hope: “…given the mounting evidence that the gut microbiome plays a fundamental role in numerous aspects of our health and disease, it can be easily envisioned that novel personalized nutritional and therapeutic approaches targeting the intestinal microbiota such as probiotics, prebiotics, nutraceuticals, functional foods, and fecal microbiota transplantation may offer potential avenues for better health and wellbeing with a particular relevance for our senior comrades.”
Considering that every one of us is getting older by the day, the time to care for you old friends is now.
[i] Nagpal, R, et. al. Gut microbiome and aging: physiological and mechanistic insights. Nutrition and Healthy Aging. 2018;4:267-285.
Category: Altzheimers, Autoimmune Disease, Bacterial Microbiome, Cardiovascular Disease, Crohn's Disease, Human Biome, inflammation, Inflammatory Bowel Disease, Irritable Bowel Syndrome, Metabolic Syndrome, microbiome, obesity, Ulcerative ColitisTags: Aging, Alzheimers, autoimmune, bacterialmicrobiome, cancer, cardiovasculardisease, Crohn's, Diabetes, Diet, gutbacteria, health, inflammatoryboweldisease, Irritablebowelsyndrome, metabolicsyndrome, microbes, Prebiotics, Probiotics, ulcerativecolitis