This morning I stumbled across some interesting research on alterations in the microbiome and Alzheimer’s Disease (AD).[i] I have written before about recent studies suggesting that such alterations lead to the amyloid deposits in the brain that are characteristics of the disease. Researchers at the University of Wisconsin-Madison, along with scientists in both Sweden and the UK, analyzed the biomes of 50 people (25 with the disease and 25 health people) by gene sequencing of the bacteria from fecal samples. Those with AD had markedly less diversity of species: in particular, they showed a decrease in Firmicutes and Bifidobacterium, and an increase in Bacteroidetes.
The authors concluded that, “The decreased richness and diversity in our study broadly parallels results observed in other conditions linked to gut microbiome alterations, including obesity, diabetes, IBD, and Parkinson’s disease….While the specific bacteria responsible for these compositional and functional alterations may differ between conditions, it has been proposed that these broad-scale changes in gut microbiota (often referred to as “dysbiosis”) may play important roles in disease progression and maintenance, potentially through immune activation and systemic inflammation.”
What I found particularly interesting is that the authors look at the specific bacterial changes and relate them to possible mechanisms of action. Two examples:
By the way, there was actually some good news in this paper. As noted above, the researchers found decreased amounts of Bifidobacterium species. These are highly anti-inflammatory and improve the health of the gut’s mucosal barrier (keeping it from becoming leaky). In a small, 12-week-long study of people with severe dementia, a probiotic that contains Bifidobacterium showed improvement in mental state examination scores.
[i] Vogt, NM, et. al. Gut microbiome alterations in Alzheimer’s disease. Scientific Reports 7. Article number: 13537 2017.
[ii] Vogt, NM, et. al. Gut microbiome alterations in Alzheimer’s disease. Scientific Reports 7. Article number: 13537 2017.
Category: Aging, Altzheimers, Bacterial Microbiome, Diabetes, Human Biome, Immune System-Brain Connection, inflammation, Mental Health, Metabolic Syndrome, microbiome, Parkinson's Disease, ProbioticsTags: ageing, Alzheimers, bacterialmicrobiome, brain, dementia, Diabetes, health, immunesystem, inflammation, mentalhealth, microbes, microbiome, Parkinson's Disease, Probiotics